Senior Bioinformatician

Nicholas C. Dove

Mayo Clinic

I'm a bioinformatician and microbial ecologist working at the intersection of computational biology and environmental science. At Mayo Clinic, I develop novel bioinformatics workflows to address complex biological questions. My research spans shotgun metagenomics, multi-omics, and plant–microbe interactions — with a focus on how microbial communities shape ecosystem function and human health.

Ph.D. · UC Merced · Postdoc · Oak Ridge National Laboratory · Previously AgBiome

Work

Projects

Ph.D. · UC Merced

Post-Fire Microbial Ecosystem Recovery

Used shotgun metagenomics and biogeochemical assays to understand how high-severity wildfire affects soil microbial communities in the Sierra Nevada. Established a fire chronosequence to track recovery trajectories over time and identify the microbial mechanisms driving — or limiting — ecosystem resilience.

MetagenomicsMicrobial EcologyFire EcologyBiogeochemistry

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Postdoc · Oak Ridge National Laboratory

Plant–Microbe Interactions Multi-Omics

Investigated the temporal dynamics of plant microbiome community assembly as part of the DOE Plant Microbe Interfaces Scientific Focus Area. Applied integrated multi-omics approaches — including metagenomics, metatranscriptomics, and metabolomics — to characterize how plants and microbes shape each other's molecular environments.

Multi-omicsPlant MicrobiomeMetatranscriptomicsMetabolomics

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AgBiome

Biosurfactant Discovery Workflows

Designed and built novel bioinformatics pipelines to support biosurfactant discovery from microbial genome databases. Demonstrated how computational approaches can accelerate early-stage R&D by identifying candidate genes and organisms — a case study in translating bioinformatics methods to address real business needs.

Pipeline DevelopmentGenomicsApplied BioinformaticsDrug Discovery

Personal Project

Chance-it

A lightweight Flask web app that pulls a list of options from a Google Sheet and randomly selects one. Built for those moments when you need a fast, shareable, zero-setup decision-maker — just drop your choices in a spreadsheet and let the app decide.

PythonFlaskGoogle Sheets APIWeb App

View on GitHub

Research

Publications

29 publications · auto-synced from Semantic Scholar

2024

Seasonality and longer-term development generate temporal dynamics in the Populus microbiome

William A. Argiroff, Alyssa A. Carrell, D. Klingeman, Nicholas C. Dove, W. Muchero, A. Veach, Toni Wahl, Steven J. Lebreux, A. Webb, Kellie Peyton, C. Schadt, M. Cregger

mSystems2024PDF

2023

Harnessing the microbial world for human benefit.

Yong Jun Goh, Brody J. DeYoung, Nicholas C. Dove, Brant R. Johnson, Matthew K. Martz, Matilda Mel, Patrick Videau

Trends in biotechnology2023

2022

Relationships between Sphaerulina musiva Infection and the Populus Microbiome and Metabolome

Nicholas C. Dove, Alyssa A. Carrell, N. Engle, D. Klingeman, Miguel Rodriguez, Toni Wahl, T. Tschaplinski, W. Muchero, C. Schadt, M. Cregger

mSystems2022PDF

Ecological and genomic responses of soil microbiomes to high-severity wildfire: linking community assembly to functional potential

Nicholas C. Dove, N. Taş, S. Hart

The ISME Journal2022PDF

Climatic controls on soil and saprock nitrogen distribution and persistence in the Sierra Nevada

K. Moreland, M. Barnes, A. O’Geen, Nicholas C. Dove, S. Hart, A. Berhe

Journal of Plant Nutrition and Soil Science2022PDF

Landscape Topography and Regional Drought Alters Dust Microbiomes in the Sierra Nevada of California

M. Maltz, C. Carey, Hannah L. Freund, Jon K. Botthoff, S. Hart, J. Stajich, S. Aarons, S. Aciego, M. Blakowski, Nicholas C. Dove, M. Barnes, Nuttapon Pombubpa, E. Aronson

Frontiers in Microbiology2022PDF

Leaf endophytic microbiomes of different almond cultivars grafted to the same rootstock

J. P. Saldierna Guzmán, Nicholas C. Dove, S. Hart

Journal of Applied Microbiology2022PDF

2021

Metabolic capabilities mute positive response to direct and indirect impacts of warming throughout the soil profile

Nicholas C. Dove, M. Torn, S. Hart, N. Taş

Nature Communications2021PDF

Depth dependence of climatic controls on soil microbial community activity and composition

Nicholas C. Dove, M. Barnes, K. Moreland, R. Graham, A. Berhe, S. Hart

ISME Communications2021PDF

Plant–Microbe Interactions: From Genes to Ecosystems Using Populus as a Model System

M. Cregger, Dana L. Carper, Stephan Christel, M. Doktycz, J. Labbé, Joshua K. Michener, Nicholas C. Dove, E. Johnston, Jessica A. M. Moore, Jessica M. Vélez, J. Morrell-Falvey, W. Muchero, D. Pelletier, S. Retterer, T. Tschaplinski, G. Tuskan, D. Weston, C. Schadt

Phytobiomes Journal2021PDF

Metagenomic tools in microbial ecology research.

N. Taş, Anniek E E de Jong, Yao-ming Li, G. Trubl, Yaxin Xue, Nicholas C. Dove

Current opinion in biotechnology2021PDF

Assembly of the Populus Microbiome Is Temporally Dynamic and Determined by Selective and Stochastic Factors

Nicholas C. Dove, A. Veach, W. Muchero, Toni Wahl, J. Stegen, C. Schadt, M. Cregger

mSphere2021PDF

Fire alters plant microbiome assembly patterns: integrating the plant and soil microbial response to disturbance

Nicholas C. Dove, D. Klingeman, Alyssa A. Carrell, M. Cregger, C. Schadt

The New Phytologist2021PDF

2020

Microorganisms in the Critical Zone: An ASSET Case Study for Sample Processing and Data Workflows, Synthesis, and Dissemination

E. Aronson, M. Maltz, D. Garijo, Keshav Arogyawsamy, Nicholas C. Dove, E. Mayorga, Hannah L. Freund, C. Bruyère, Michael D. Daniels

Goldschmidt Abstracts2020PDF

Microbiome Variation Across Two Hemlock Species With Hemlock Woolly Adelgid Infestation

Nicholas C. Dove, T. Rogers, Christy Leppanen, D. Simberloff, J. Fordyce, V. Brown, A. LeBude, T. Ranney, M. Cregger

Frontiers in Microbiology2020PDF

High-severity wildfire leads to multi-decadal impacts on soil biogeochemistry in mixed-conifer forests.

Nicholas C. Dove, H. Safford, Gabrielle N. Bohlman, B. Estes, S. Hart

Ecological applications : a publication of the Ecological Society of America2020PDF

Continental-scale patterns of extracellular enzyme activity in the subsoil: an overlooked reservoir of microbial activity

Nicholas C. Dove, K. Arogyaswamy, S. Billings, Jon K. Botthoff, C. Carey, Caitlin Cisco, J. DeForest, D. Fairbanks, N. Fierer, R. Gallery, J. Kaye, K. Lohse, M. Maltz, E. Mayorga, J. Pett‐Ridge, Wendy H. Yang, S. Hart, E. Aronson

Environmental Research Letters2020PDF

2019

Soil microbial ecology of the Sierra Nevada: Predictions for a warm and fiery future

Nicholas C. Dove

2019

Thermal Acclimation of Soil Microbial Communities Declines with Depth

N. Taş, S. Hart, M. Torn, Nicholas C. Dove

2019

Carbon control on terrestrial ecosystem function across contrasting site productivities: the carbon connection revisited.

Nicholas C. Dove, J. Stark, G. S. Newman, S. Hart

Ecology2019PDF

Competing droughts affect dust delivery to Sierra Nevada

S. Aarons, L. Arvin, S. Aciego, C. Riebe, K. Johnson, M. Blakowski, J. Koornneef, S. Hart, M. Barnes, Nicholas C. Dove, Jon K. Botthoff, M. Maltz, E. Aronson

Aeolian Research2019PDF

Ecological and Genomic Attributes of Novel Bacterial Taxa That Thrive in Subsurface Soil Horizons

Tess E. Brewer, E. Aronson, K. Arogyaswamy, S. Billings, Jon K. Botthoff, A. Campbell, Nicholas C. Dove, D. Fairbanks, R. Gallery, S. Hart, J. Kaye, G. King, Geoffrey D. Logan, K. Lohse, M. Maltz, E. Mayorga, Caitlin O'Neill, S. Owens, A. Packman, J. Pett‐Ridge, A. Plante, D. Richter, W. Silver, Wendy H. Yang, N. Fierer

mBio2019PDF